为深化科研体制机制改革，全面提升科研创新能力，加快推动科研高质量发展，北京师范大学科研院和北京师范大学化学学院邀请国内外知名学者和名师大家，打造系列高水平学术讲座“京师杏坛大讲堂”。
一、组织单位
主办：北京师范大学科研院、北京师范大学化学学院
二、主讲人介绍
Carolyn Bertozzi
斯坦福大学Anne T. and Robert M. Bass讲席教授，霍华德休斯医学研究所研究员，美国国家科学院、艺术与科学院、医学院、发明家科学院院士，2022年诺贝尔化学奖得主。Carolyn Bertozzi教授于1988年从哈佛大学获得化学学士学位，1993年获加州大学伯克利分校化学博士学位。在加州大学旧金山分校完成细胞免疫学领域的博士后研究后，于1996年加入加州大学伯克利分校开展独立研究，2015年6月加入斯坦福大学。Carolyn Bertozzi教授的研究横跨化学与生物学领域，关注疾病相关糖生物学并开发全新治疗方法，开创了“生物正交化学”这一研究领域。
Carolyn Bertozzi is the Anne T. and Robert M. Bass Professor of Chemistry and Professor of Chemical & Systems Biology and Radiology (by courtesy) at Stanford University, and an Investigator of the Howard Hughes Medical Institute. She completed her undergraduate degree in Chemistry from Harvard University in 1988 and her Ph.D. in Chemistry from UC Berkeley in 1993. After completing postdoctoral work at UCSF in the field of cellular immunology, she joined the UC Berkeley faculty in 1996. In June 2015, she joined the faculty at Stanford University coincident with the launch of Stanford's Sarafan ChEM-H Institute.Prof. Bertozzi's research interests span the disciplines of chemistry and biology with an emphasis on developing new therapeutic modalities that target disease-related glycobiology. She founded the field of bioorthogonal chemistry, for which she shared the 2022 Nobel Prize in Chemistry. Her group has invented targeted enzyme therapeutics for immune oncology, Lysosome Targeting Chimeras (LYTACs) for extracellular targeted protein degradation, antibody-lectin chimeras (AbLecs) for therapeutic applications, and site-specific bioconjugation methods for synthesis of next-gen antibody-drug conjugates. Her lab has also developed glycoproteomics technologies for disease biomarker discovery, point-of-care diagnostics for tuberculosis, and ultrasensitive antibody detection methods that are being used to diagnose early onset diabetes and viral infections. Her academic work has launched 12 co-founded biotechnology companies.Prof. Bertozzi has been recognized with many honors and awards. She is an elected member of the Institute of Medicine, National Academy of Sciences, National Academy of Inventors and American Academy of Arts and Sciences. In addition to the Nobel Prize, she received the Welch Award in Chemistry, Heineken Prize for Biochemistry and Biophysics, Lemelson-MIT Prize, and a MacArthur Foundation Fellowship. She received the 2024 Priestley Medal from the American Chemical Society.
三、报告主题
Bioorthogonal chemistry: from basic science to clinical translation
四、报告摘要
Chemistry designed for living systems, termed "bioorthogonal chemistry", has enabled new approaches for biological research. We initially developed these reactions for applications to glycobiology, which led to the discovery of new roles for cell-surface glycans in cancer and new types of glycoconjugates including glycoRNA. Bioorthgonal and related click chemistry reactions are now impacting drug development by enabling new approaches to bioconjugate drugs (e.g., antibody-drug conjugates). This presentation will overview the history of the field and recent examples of clinical translation.
五、报告时间及地点
时间：2025年8月29日上午10:30
地点：化学楼二楼学术报告厅